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But what some people dont understand is that when they stop taking the medication, they may gain all that weight back. (The current study did not evaluate weight gain after the discontinuation of GLP-1 medications.) GLP-1 medications act as a pharmaceutical version of a natural hormone in the gut, lowering blood sugar, keeping you feeling fuller longer, and slowing down digestion

According research (Koropatkin and Martens, 2017), when metformin is administered orally, its bioavailability is about 50%, and it is higher compared to intravenous administration

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